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• Study of the peptidome: all the peptides present in a particular cell, tissue or organism at a particular point in time • BUT: most peptide extracts consist largely of degradation products of proteins (and not endogenous tissue peptides): fragmentomics, degradomics • Breakthrough peptidomics technology [1], [2] permits preparation of extracts devoid of degradation products • Peptide analysis and identification by nanoLC-MS? • Validated on mouse pituitary (all known pituitary peptides identified) • Analysis of all peptides in tissue sample or body fluid (peak pattern) • Comparison of peptides in different samples (differential peptidomics) • Identification of peptides by tandem MS for species whose genome is known • Use: biomarkers discovery, elucidation mechanism of action, … • Fee for service or scientific collaboration • Contact Dr. Geert Baggerman (
Tel:+32 16 330458 or +32 16 345700; Fax:+32 16 345995) • http://www.prometa.kuleuven.be/ |
